Cartilage Degradation in Osteoarthritis

Glucose Transport and Metabolism in Chondrocytes – a Key to Understanding Chondrogenesis, Skeletal Development and Cartilage Degradation in Osteoarthritis

Article Summary:

There are many mechanisms which affect the continued degradation associated with arthritis. Glucose and its derivatives are important in the building of cartilage and repairing damage. Chondrocytes utilize the glucosamine sulfate to build the extra cellular matrix, or the bone and joint tissues. One possible explanation for arthritis may be a disorder of the usage of glucose and therefore a failure to fully create and repair cartilage. The use of glucosamine then is one supplement that may help to correct the metabolic disorder and lead to the repair of the degradation and the alleviation of pain.

Authors:
Mobasheri A. Vannucci SJ. Bondy CA. Carter SD. Innes JF. Arteaga MF. Trujillo E. Ferraz I. Shakibaei M. Martin-Vasallo P.

Institution:
Connective Tissue Research Group, Musculoskeletal Physiology Laboratory, Faculty of Veterinary Science, University of Liverpool, Liverpool, United Kingdom. a.mobasheri@liverpool.ac.uk

Country of Publication:
Spain

Source:
Histology & Histopathology. 17(4):1239-67, 2002 Oct.

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