Glucosamine and Ibuprofen

Double-Blind Clinical Evaluation of the Relative Efficacy of Ibuprofen and Glucosamine in the Management of Osteoarthrosis of the Knee in Outpatients.

Summary:

Patients with osteoarthritis of the knee were separated into two groups and given either 1.5g of glucosamine sulfate or 1.2g of ibuprofen daily. Neither the patients nor the researchers were aware of which group the patient was in, as to eliminate as much bias as possible. Initially, the ibuprofen group showed faster decreases in pain, but the patients taking the glucosamine reported lower rates of pain over a longer period of time, and eventually reported less pain than those taking ibuprofen. There was a general well tolerance to the glucosamine and side effects were negligible.

Authors:
Antonio Lopes Vaz, M.D.

Institution:
St. John Hospital, Oporto, Portugal

Source:
Current Medical Research and Opinion Vol.8, No. 3, 1982

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